北京索莱宝科技
专注于生物学试剂及试剂盒领域
服务热线：18101056239
专注于生物学试剂及试剂盒领域
服务热线：18101056239
产品型号：K200027M
更新时间：2022-08-15
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Anti-Cleaved PARP Monoclonal Antibody
| 英文名称 | Anti-Cleaved PARP Monoclonal Antibody |
|---|---|
| 宿主 | Mouse |
| 别名 | PARP-1; Poly(ADP ribose) polymerase 1; sPARP1;ADPRT1; ADP ribosyltransferase NAD(+) |
| 应用 | WB |
| 稀释比例 | WB 1:1000-3000. |
| 交叉反应 | Human |
| 蛋白分子量 | 116kDa(Pro)89kDa(Active) |
| Gene ID | 142 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG1 |
| 免疫原 | A synthetic peptide coupled to KLH |
| 性状 | 液体 |
| Public Immunogen Range | A synthetic peptide coupled to KLH |
| Subcellular Locations | Nucleus |
| Swiss Prot | P09874 |
| 克隆号 | M4 |
| 克隆类型 | Monoclonal Antibody |
| 背景资料 | Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate. |
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